Literature summary for 2.3.1.26 extracted from

Thewke, D.; Freeman-Anderson, N.; Pickle, T.; Netherland, C.; Chilton, C.
AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors (2009), Biochem. Biophys. Res. Commun., 381, 181-186.

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Inhibitors

Inhibitors	Comment	Organism	Structure
AM-251	selective antagonist of cannobinoid receptor CB1. Additionally, reatment of cells reduces cholesteryl ester synthesis in unstimulated and acetylated low densitixy lipoprotein-stimulated Raw 264.7 macrophages, CB2 +/+ and CB2-/- peritoneal macrophages, as well as in vitro, in mouse liver microsomes. Consistent with inhibition of ACAT, the development of foam cell characteristics in macrophages by treatment with acetylated low density lipoprotein is reduced	Mus musculus
SR144528	selective antagonist of cannobinoid receptor CB1. Additionally, reatment of cells reduces cholesteryl ester synthesis in unstimulated and acetylated low densitixy lipoprotein-stimulated Raw 264.7 macrophages, CB2 +/+ and CB2-/- peritoneal macrophages, as well as in vitro, in mouse liver microsomes. Consistent with inhibition of ACAT, the development of foam cell characteristics in macrophages by treatment with acetylated low density lipoprotein is reduced	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

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Release 2023.1 (January 2023)