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Literature summary for 2.3.1.26 extracted from
- The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo (2007), Eur. J. Pharmacol., 576, 114-121.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the results suggest that this novel hypolipidaemic agent exert antiarrhythmic and infarct size-limiting effects in the diabetic-hypercholesterolaemic rat heart | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| VULM 1457 | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| rough endoplasmic reticulum | - |
Rattus norvegicus | 5791 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | Rattus norvegicus | - |
CoA + cholesterol ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male wistar rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesterol ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACAT | - |
Rattus norvegicus |
| acyl-CoA:cholesterol acyltransferase | - |
Rattus norvegicus |
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