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Literature summary for 2.3.1.26 extracted from

  • Lee, J.H.; Ryu, Y.B.; Lee, B.W.; Kim, J.H.; Lee, W.S.; Park, Y.; Jeong, T.; Park, K.H.
    Human acyl-CoA:cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) merr (2008), Bull. Korean Chem. Soc., 29, 615-619.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
using the baculovirus system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(24R)-ethylcholest-5-ene-3,7-diol
-
Homo sapiens
3beta-hydroxylup-20(29)-en-28-oic acid
-
Homo sapiens
5alpha,8alpha-epidioxy-24(R)-methylcholesta-6,22-diene-3beta-ol
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
CoA + cholesterol ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-1 are used as sources of the enzyme Homo sapiens
microsomal fractions of Hi5 cells containing baculovirally expressed hACAT-2 are used as sources of the enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
Homo sapiens CoA + cholesterol ester
-
?
oleoyl-CoA + cholesterol activity assay Homo sapiens CoA + cholesteryl oleate
-
?
oleoyl-CoA + cholesterol activity assay Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
acyl-CoA:cholesterol acyltransferase
-
Homo sapiens
hACAT-1
-
Homo sapiens
hACAT-2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
activity assay Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0115
-
-
Homo sapiens 3beta-hydroxylup-20(29)-en-28-oic acid
0.025
-
-
Homo sapiens (24R)-ethylcholest-5-ene-3,7-diol
0.0339
-
-
Homo sapiens 3beta-hydroxylup-20(29)-en-28-oic acid
0.0387
-
-
Homo sapiens 5alpha,8alpha-epidioxy-24(R)-methylcholesta-6,22-diene-3beta-ol
0.102
-
-
Homo sapiens (24R)-ethylcholest-5-ene-3,7-diol
0.2
-
-
Homo sapiens 5alpha,8alpha-epidioxy-24(R)-methylcholesta-6,22-diene-3beta-ol