Application | Comment | Organism |
---|---|---|
medicine | isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro | Homo sapiens |
medicine | isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro. In vivo ceramide reduction by inhibition of de novo ceramide synthesis reduces PLIN2 and hepatic steatosis in alcohol-fed mice, and improves glucose homeostasis in control and Etoh mice, but only de novo synthesis inhibition. Inhibition of ceramide synthesis during alcohol feeding has minimal effect on body composition, food intake, and energy expenditure | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6ZMG9 | - |
- |
Mus musculus | Q8C172 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
HepG2-VL17A cell | human hepatoma HepG2 cells stably transfected with recombinant plasmids carrying the murine alcohol dehydrogenase gene and the human cytochrome P450 2E1 gene, in vitro model of alcoholic steatosis | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Mus musculus | CerS6 is upregulated in alcoholic steatosis | up |
Homo sapiens | CerS6 is upregulated in alcoholic steatosis and in response to ethanol | up |
General Information | Comment | Organism |
---|---|---|
physiological function | nonspecific CerS reduction with fumonisin B1 reduces PLIN2 protein | Homo sapiens |