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Literature summary for 2.3.1.20 extracted from

  • Jin, Y.; McFie, P.J.; Banman, S.L.; Brandt, C.; Stone, S.J.
    Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis (2014), J. Biol. Chem., 289, 28237-28248.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.20

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells, RH-7777 cells, and COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
lipid droplet
-
 Homo sapiens 5811
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 2 * 42000, SDS-PAGE Homo sapiens
90000
-
 gel filtration, the enzyme is part of large 650000 Da protein complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1,2-diacyl-sn-glycerol Homo sapiens
-
 CoA + triacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1,2-diacyl-sn-glycerol
-
 Homo sapiens CoA + triacylglycerol
-
 ?
additional information the enzyme interacts with monoacylglycerol acyltransferase-2 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 42000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
acyl CoA:1,2-diacylglycerol acyltransferase
-
 Homo sapiens
DGAT2
-
 Homo sapiens
diacylglycerol acyltransferase-2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme interacts with lipid droplets presumably to catalyze localized triacylglycerol synthesis for lipid droplet expansion Homo sapiens