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Literature summary for 2.3.1.20 extracted from

  • Li, C.; Li, L.; Lian, J.; Watts, R.; Nelson, R.; Goodwin, B.; Lehner, R.
    Roles of acyl-CoA:diacylglycerol acyltransferases 1 and 2 in triacylglycerol synthesis and secretion in primary hepatocytes (2015), Arterioscler. Thromb. Vasc. Biol., 35, 1080-1091.
    View publication on PubMed
Search for more literature for 2.3.1.20

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylcholine
-
 Mus musculus
phosphatidylethanolamine
-
 Mus musculus
phosphatidylinositol
-
 Mus musculus
phosphatidylserine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1,2-diacyl-sn-glycerol Mus musculus isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol CoA + triacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 1,2-diacetyl-sn-glycerol
-
 Mus musculus CoA + triacetylglycerol
-
 ?
acyl-CoA + 1,2-diacyl-sn-glycerol isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol Mus musculus CoA + triacylglycerol
-
 ?
oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
 Mus musculus CoA + trioleoylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
acyl-CoA:diacylglycerol acyltransferase 1
-
 Mus musculus
acyl-CoA:diacylglycerol acyltransferase 2
-
 Mus musculus
DGAT1
-
 Mus musculus
DGAT2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Isoform DGAT1 inactivation promotes large lipid droplet formation. Inhibition of isoform DGAT2 augments fatty acid oxidation, whereas inhibition of DGAT1 increases triacylglycerol secretion. Triacylglycerol secretion is significantly reduced on DGAT2 inhibition without altering extracellular apolipoprotein B levels Mus musculus
metabolism the triacylglycerol pool generated by DGAT1 is preferentially used for supplying substrates for oxidation, whereas DGAt2-derived triacylglycerol is more favored for secretion Mus musculus