Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | an isoform DGAT2 mutant lacking both its transmembrane domains still associates with membranes, but is absent from the endoplasmic reticulum and instead localizes to mitochondria. The mutant is still active and capable of interacting with lipid droplets to promote triacylglycerol storage. Mutants, in which regions of the C-terminus are either truncated or specific regions are deleted, fail to co-localize with lipid droplets when cells are loaded with oleate to stimulate triacylglycerol synthesis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | the endoplasmic reticulum targeting signal is present in the first transmembrane domain, TMD1, of isoform DGAT2 | Mus musculus | 5783 | - |
lipid droplet | the interaction of isoform DGAT2 with lipid droplets is dependent on the C-terminus. Mutants, in which regions of the C-terminus are either truncated or specific regions are deleted, failed to co-localize with lipid droplets when cells are oleate loaded to stimulate triacylglycerol synthesis | Mus musculus | 5811 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9DCV3 | isoform DGAT2 | - |
Source Tissue | Comment | Organism | Textmining |
---|
Subunits | Comment | Organism |
---|---|---|
More | individual isoform DGAT2 subunits are capable of interacting as part of a multimeric complex. Multiple domains, both in the N and C termini, mediate subunit interaction | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
DGAT2 | - |
Mus musculus |