Inhibitors | Comment | Organism | Structure |
---|---|---|---|
betulinic acid | a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, inhibition of Hep-G2 cell triacyglycerol biosynthesis | Homo sapiens | |
betulinic acid | a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, noncompetitive inhibition, IC50: 0.0096 mM | Rattus norvegicus | |
kuraridin | IC50: 0.0098 mM | Rattus norvegicus | |
oleate | noncompetitive inhibition, IC50: 0.0545 mM | Homo sapiens | |
oleoyl-CoA | substrate inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0133 | - |
oleoyl-CoA | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dioleoylglycerol + oleoyl-CoA | Rattus norvegicus | - |
triolein + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dioleoylglycerol + oleoyl-CoA | - |
Rattus norvegicus | triolein + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGAT | - |
Homo sapiens |
DGAT | - |
Rattus norvegicus |
diacylglycerol acyltransferase | - |
Homo sapiens |
diacylglycerol acyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0081 | - |
oleoyl-CoA | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0096 | - |
a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, noncompetitive inhibition, IC50: 0.0096 mM | Rattus norvegicus | betulinic acid | |
0.0098 | - |
IC50: 0.0098 mM | Rattus norvegicus | kuraridin | |
0.0545 | - |
noncompetitive inhibition, IC50: 0.0545 mM | Homo sapiens | oleate |