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Literature summary for 2.3.1.20 extracted from

  • Chung, M.Y.; Rho, M.C.; Lee, S.W.; Park, H.R.; Kim, K.; Lee, I.A.; Kim, D.H.; Jeune, K.H.; Lee, H.S.; Kim, Y.K.
    Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta (2006), Planta Med., 72, 267-269.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
betulinic acid a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, inhibition of Hep-G2 cell triacyglycerol biosynthesis Homo sapiens
betulinic acid a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, noncompetitive inhibition, IC50: 0.0096 mM Rattus norvegicus
kuraridin IC50: 0.0098 mM Rattus norvegicus
oleate noncompetitive inhibition, IC50: 0.0545 mM Homo sapiens
oleoyl-CoA substrate inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0133
-
oleoyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-dioleoylglycerol + oleoyl-CoA Rattus norvegicus
-
triolein + CoA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoylglycerol + oleoyl-CoA
-
Rattus norvegicus triolein + CoA
-
?

Synonyms

Synonyms Comment Organism
DGAT
-
Homo sapiens
DGAT
-
Rattus norvegicus
diacylglycerol acyltransferase
-
Homo sapiens
diacylglycerol acyltransferase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0081
-
oleoyl-CoA
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0096
-
a lupane-type triterpenoid, isolated from methanolic extracts of Alnus hirsuta, noncompetitive inhibition, IC50: 0.0096 mM Rattus norvegicus betulinic acid
0.0098
-
IC50: 0.0098 mM Rattus norvegicus kuraridin
0.0545
-
noncompetitive inhibition, IC50: 0.0545 mM Homo sapiens oleate