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Literature summary for 2.3.1.20 extracted from

  • Millar, J.S.; Stone, S.J.; Tietge, U.J.; Tow, B.; Billheimer, J.T.; Wong, J.S.; Hamilton, R.L.; Farese, R.V.; Rader, D.J.
    Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production (2006), J. Lipid Res., 47, 2297-2305.
    View publication on PubMed
Search for more literature for 2.3.1.20

Cloned(Commentary)

Cloned (Comment) Organism
short-term hepatic overexpression of DGAT1 in mice using adenoviral vectors results in 2.0fold increases in the triglyceride content of liver, the increase in hepatic triglyceride content has no effect on the production rate of VLDL triglyceride or apoB Mus musculus
short-term hepatic overexpression of DGAT2 in mice using adenoviral vectors results in 2.4fold increases in the triglyceride content of liver, the increase in hepatic triglyceride content has no effect on the production rate of VLDL triglyceride or apoB Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information short-term overexpression of DGAT1 increases hepatic triglyceride but not VLDL triglyceride or apoB production, overview Mus musculus
additional information short-term overexpression of DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 x * 45000, recombinant DGAT2, SDS-PAGE Mus musculus
47000
-
 x * 47000, recombinant DGAT1, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus increasing the cytoplasmic triglyceride pool in hepatocytes does not directly influence VLDL triglyceride or apoB production, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9DCV3 gene DGAT2; gene DGAT2
-
Mus musculus Q9Z2A7 gene DGAT1; gene DGAT1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 plasma and liver lipid levels of wild-type mice compared to recombinant DGAT1 overexpressing mice Mus musculus
additional information
-
 plasma and liver lipid levels of wild-type mice compared to recombinant DGAT2 overexpressing mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information increasing the cytoplasmic triglyceride pool in hepatocytes does not directly influence VLDL triglyceride or apoB production, overview Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, recombinant DGAT2, SDS-PAGE Mus musculus
? x * 47000, recombinant DGAT1, SDS-PAGE Mus musculus