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Literature summary for 2.3.1.20 extracted from

  • Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
    The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters (2005), J. Lipid Res., 46, 1502-1511.
    View publication on PubMed
Search for more literature for 2.3.1.20

Cloned(Commentary)

Cloned (Comment) Organism
DGAT1, functional expression of the FLAG-tagged enzyme in membranes of Spodoptera frugiperda Sf9 cells and in COS-7 cells, expression analysis Mus musculus
DGAT2, functional expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells, expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information DGAT2 overexpression also increases wax monoester synthase activity in intact cells Mus musculus
additional information the wax diester synthase activity of DGAT1 helps to explain the deficiency of type II wax diesters in the fur lipids of Dgat-/- mice, DGAT1 deficiency also perturbs retinol metabolism in the livers of Dgat-/- mice, hepatic levels of unesterified retinol are increased in Dgat-/- mice challenged with high-retinol diets Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-dioleoylglycerol + palmitoyl-CoA Mus musculus
-
 1,2-dioleoyl-3-palmitoylglycerol + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9DCV3 DGAT2
-
Mus musculus Q9Z2A7 DGAT1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
additional information expression analysis Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
 recombinant enzyme in Sf9 cell membrane and in COS-7 cell membranes, multifunctional enzyme Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoylglycerol + palmitoyl-CoA
-
 Mus musculus 1,2-dioleoyl-3-palmitoylglycerol + CoA
-
 ?
additional information DGAT1 is also catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview Mus musculus ?
-
 ?
additional information DGAT1 is catalyzing the reactions of the monoacylglycerol transferase, EC 2.3.1.22, of the diacylglycerol transferase, EC 2.3.1.20, of the wax synthase, EC 2.3.1.75, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
DGAT
-
 Mus musculus