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Literature summary for 2.3.1.20 extracted from
- The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana (2005), Arch. Pharm. Res., 28, 164-168.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid | IC50: 0.0443 mM | Rattus norvegicus |  |
| brachynereolide | IC50: 0.25 mM, above | Rattus norvegicus | |
| crepidiaside C | IC50: 0.25 mM, above | Rattus norvegicus | |
| cryptotanshinone | IC50: 0.0273 mM | Rattus norvegicus | |
| germanicol acetate | IC50: 0.25 mM, above | Rattus norvegicus | |
| ixerin Y | IC50: 0.25 mM, above | Rattus norvegicus | |
| methyl ursolate | IC50: 0.0264 mM | Rattus norvegicus | |
| additional information | an ethylacetic extract of Youngia koidzumiana, a plant endemic to the Mount Chiri region of Korea, significantly inhibits the liver microsome enzyme | Rattus norvegicus | |
| oleanolic acid | IC50: 0.0317 mM | Rattus norvegicus | |
| sesquiterpenoids | weak inhibition | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme partially by microsome preparation | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dioleoyl-sn-glycerol + palmitoyl-CoA | - |
Rattus norvegicus | 1,2-dioleoyl-3-palmitoyl-sn-glycerol + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DGAT | - |
Rattus norvegicus |
| diacylglycerol acyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0264 | - |
IC50: 0.0264 mM | Rattus norvegicus | methyl ursolate | |
| 0.0273 | - |
IC50: 0.0273 mM | Rattus norvegicus | cryptotanshinone | |
| 0.0317 | - |
IC50: 0.0317 mM | Rattus norvegicus | oleanolic acid | |
| 0.0443 | - |
IC50: 0.0443 mM | Rattus norvegicus | (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid | |
| 0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | brachynereolide | |
| 0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | ixerin Y | |
| 0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | crepidiaside C | |
| 0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | germanicol acetate | |
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