Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucose | treatment of adipocytes with glucose increases DGAT1 mRNA | Mus musculus | |
Insulin | treatment of adipocytes with insulin increases DGAT2 mRNA | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacylglycerol | Mus musculus | DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver | CoA + triacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | 3T3-L1 fibroblasts differentiated into adipocytes | Mus musculus | - |
adipocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0003 | - |
membrane fraction after insulin-starvation | Mus musculus |
0.00036 | - |
membrane fraction after carbohydrate-starvation | Mus musculus |
0.00265 | - |
membrane fraction | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacylglycerol | DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver | Mus musculus | CoA + triacylglycerol | - |
? |