Literature summary for 2.3.1.181 extracted from

Ma, Q.; Zhao, X.; Nasser Eddine, A.; Geerlof, A.; Li, X.; Cronan, J.E.; Kaufmann, S.H.; Wilmanns, M.
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase (2006), Proc. Natl. Acad. Sci. USA, 103, 8662-8667.

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Application

Application	Comment	Organism
medicine	enzyme is considerably upregulated in patients with multiple-drug-resistant Mycobacterium tuberculosis	Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme shows thioether-linked active site complex with decanoic acid. Structural comparison with lipoate protein ligase A	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WK83	enzyme is considerably upregulated in patients with multiple-drug-resistant Mycobacterium tuberculosis	-
Mycobacterium tuberculosis H37Rv	P9WK83	enzyme is considerably upregulated in patients with multiple-drug-resistant Mycobacterium tuberculosis	-

Reaction

Reaction	Comment	Organism	Reaction ID
octanoyl-[acyl-carrier protein] + protein = protein 6-N-(octanoyl)lysine + acyl carrier protein	enzyme functions as a cysteine/lysine dyad acyltransferase, where K142 and C176 are acid/base catalysts. Reaction proceeds via an internal thioester intermediate	Mycobacterium tuberculosis	a

Synonyms

Synonyms	Comment	Organism
LipB	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)