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Literature summary for 2.3.1.180 extracted from

  • Zhang, H.J.; Zhu, D.D.; Li, Z.L.; Sun, J.; Zhu, H.L.
    Synthesis, molecular modeling and biological evaluation of beta-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents (2011), Bioorg. Med. Chem., 19, 4513-4519.
    View publication on PubMed
Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged protein expressed in Escherichia coli BL21(DE3) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate
-
 Escherichia coli
(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate
-
 Escherichia coli
Cinnamic acid
-
 Escherichia coli
secnidazole
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography (Ni2+) Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonyl-ACP + acetyl-CoA
-
 Escherichia coli CO2 + CoA + acetoacetyl-ACP
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Escherichia coli
FabH
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate
0.0067
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate
0.0082
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate
0.0094
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate
0.0156
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate
0.0198
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate
0.0275
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate
0.0285
-
 pH 7.0, temperature not specified in the publication Escherichia coli secnidazole
0.0343
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate
0.0401
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate
0.0434
-
 pH 7.0, temperature not specified in the publication Escherichia coli Cinnamic acid
0.0489
-
 pH 7.0, temperature not specified in the publication Escherichia coli (E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate