Application | Comment | Organism |
---|---|---|
drug development | FabH is a particularly attractive target for design of antibacterial agents since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram positive and negative bacteria | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol | - |
Escherichia coli | |
2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol | - |
Escherichia coli | |
2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole | - |
Escherichia coli | |
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole | - |
Escherichia coli | |
4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol | - |
Escherichia coli | |
4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol | - |
Escherichia coli | |
4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | - |
Escherichia coli | |
additional information | inhibitor design and synthesis, analysis of inhibitory potencies against FabH and antibacterial activities, overview | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene fabH | - |
Synonyms | Comment | Organism |
---|---|---|
ACP synthase III | - |
Escherichia coli |
beta-ketoacylacylcarrier protein synthase III | - |
Escherichia coli |
FabH | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0036 | - |
- |
Escherichia coli | 2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0068 | - |
- |
Escherichia coli | 4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0117 | - |
- |
Escherichia coli | 4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0165 | - |
- |
Escherichia coli | 2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0396 | - |
- |
Escherichia coli | 4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0434 | - |
- |
Escherichia coli | 4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0576 | - |
- |
Escherichia coli | 2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol | |
0.0784 | - |
- |
Escherichia coli | 2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol |
General Information | Comment | Organism |
---|---|---|
physiological function | FabH is central to the initiation of fatty acid biosynthesis | Escherichia coli |