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Literature summary for 2.3.1.169 extracted from

  • Ito, M.; Kotera, M.; Matsumoto, T.; Tatsumi, K.
    Dinuclear nickel complexes modeling the structure and function of the acetyl CoA synthase active site (2009), Proc. Natl. Acad. Sci. USA, 106, 11862-11866.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
Nickel synthesis of a dinuclear nickel complex with methyl and thiolate ligands, Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate)Ni(Me)(2,6-dimesitylphenyl) as a dinuclear Nid-Nip-site model of acetyl-CoA synthase. The reaction of Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate)Ni(Me)(2,6-dimesitylphenyl) withexcess CO affords the acetylthioester CH3C(O)-2,6-dimesitylphenyl with concomitant formation of Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate)Ni(CO)2 and Ni(CO)4 plus Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate). When complex Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate)Ni(Me)(2,6-dimesitylphenyl) is treated with 1 equiv of CO in the presence of excess 1,5-cyclooctadiene, the formation of Ni(N,N'-diethyl-3,7-diazanonane-1,9-dithiolate)Ni(CO)2 and Ni(CO)4 is considerably suppressed, and instead the dinuclear Ni(II)-Ni(0) complex is generated in situ. The results suggest that ACS catalysis could include the Nid(II)-Nip(0) state as the active species, that the Nid(II)-Nip(0) species could first react with methylcobalamin to afford Nid(II)-Nip(II)Β–Me, and that CO insertion into the Nip-Me bond and the successive reductive elimination of acetyl-CoA occurs immediately when CoA is coordinated to the Nip site to form the active Nid(II)-Nip(0) species synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
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