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Literature summary for 2.3.1.168 extracted from

  • Ansari, A.A.; Neckelmann, N.; Villinger, F.; Leung, P.; Danner, D.J.; Brar, S.S.; Zhao, S.; Gravanis, M.B.; Mayne, A.; Gershwin, M.E.
    Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy (1994), J. Immunol., 153, 4754-4765.
    View publication on PubMed
Search for more literature for 2.3.1.168

Cloned(Commentary)

Cloned (Comment) Organism
cloning of full length E2 and fragments, expression in Escherichia coli JM109 as fusion protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information
-
 Bos taurus
additional information inhibition tests of the multienzyme complex with sera from patients suffering the possibly autoimmune diseases idopathic dilated cardiomyopathy and dilated cardiomyopathy to perform epitope mapping, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is a mitochondrial autoantigen, epitope mapping is performed to define the recognition sites by sera and T cells of patients suffering idopathic dilated cardiomyopathy and dilated cardiomyopathy ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus
recombinant E2 fusion protein from Escherichia coli, the tag is cleaved off by factor Xa Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-
liver
-
 Homo sapiens
-
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Homo sapiens CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?
2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine
-
 Bos taurus CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
-
 ?
additional information enzyme is a mitochondrial autoantigen, epitope mapping is performed to define the recognition sites by sera and T cells of patients suffering idopathic dilated cardiomyopathy and dilated cardiomyopathy Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
More enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase Homo sapiens
More enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase Bos taurus