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Literature summary for 2.3.1.167 extracted from

  • Onrubia, M.; Moyano, E.; Bonfill, M.; Palazon, J.; Goossens, A.; Cusido, R.M.
    The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets (2011), Plant Sci., 181, 282-287.
    View publication on PubMed
Search for more literature for 2.3.1.167

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 10-deacetylbaccatin III Taxus baccata
-
 CoA + baccatin III
-
 ?

Organism

Organism UniProt Comment Textmining
Taxus baccata
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aerial part
-
 Taxus baccata
-
additional information higher content of 10-deacetylbaccatin III in the aerial part of the plantlets than in the roots Taxus baccata
-
root
-
 Taxus baccata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 10-deacetylbaccatin III
-
 Taxus baccata CoA + baccatin III
-
 ?

Synonyms

Synonyms Comment Organism
10-deacetylbaccatin III-10beta-O-acetyltransferase
-
 Taxus baccata
DBAT
-
 Taxus baccata

General Information

General Information Comment Organism
metabolism the relationship between taxane patterns and the expression of genes encoding the enzymes taxadiene synthase, 10-deacetylbaccatin III-10beta-O-acetyltransferase, baccatin III 13-O-(3-amino-3-phenylpropanoyl) transferase and 3'-N-debenzoyl-2'-deoxytaxol-N-benzoyltransferase, involved in early and late steps of the taxane pathway, overview. The most abundant taxane in the aerial parts is 10-deacetylbaccatin III, which increases as the plantlets grow, indicating a low conversion to baccatin III and taxol. In contrast, the levels of 10-deacetylbaccatin III in the roots remain lower than those of taxol. But in the aerial parts the expression of DBAT, which codes for the enzyme that converts 10-deacetylbaccatin III into baccatin III, does not increase with the age of plantlets, unlike that of the other three enzymes, suggesting that this gene controls a rate-limiting step in the taxane biosynthetic pathway Taxus baccata