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Literature summary for 2.3.1.16 extracted from
- Modulation of fatty acids oxidation in heart failure by selective pharmacological inhibition of 3-ketoacyl coenzyme-A thiolase (2007), Curr. Clin. Pharmacol., 2, 190-196.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | 3-ketoacyl coenzyme-A thiolase inhibition could be a treatment for patients with heart failure | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ranolazine | - |
Homo sapiens |  |
| trimetazidine | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + acetyl-CoA | Homo sapiens | - |
CoA + 3-oxoacyl-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + acetyl-CoA | - |
Homo sapiens | CoA + 3-oxoacyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-KAT | - |
Homo sapiens |
| 3-ketoacyl coenzyme-A thiolase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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