Cloned (Comment) | Organism |
---|---|
gene als, amino acid sequence determination and analysis, sequence comparisons | Lactococcus lactis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 pyruvate | Lactococcus lactis | - |
2-acetolactate + CO2 | - |
? | |
2 pyruvate | Lactococcus lactis IL1403 | - |
2-acetolactate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lactococcus lactis | - |
- |
- |
Lactococcus lactis | Q7DAV2 | gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als | - |
Lactococcus lactis IL1403 | - |
- |
- |
Lactococcus lactis IL1403 | Q7DAV2 | gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | growth conditions and pH-dependencies of wild-type and mutant als strains, overview | Lactococcus lactis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 pyruvate | - |
Lactococcus lactis | 2-acetolactate + CO2 | - |
? | |
2 pyruvate | - |
Lactococcus lactis IL1403 | 2-acetolactate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-acetolactate synthase | - |
Lactococcus lactis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Lactococcus lactis |
General Information | Comment | Organism |
---|---|---|
malfunction | the als defective strain, which is incapable of producing C4 compounds, appears sensitive to pyruvate under acidic conditions rendering it unable to grow. Accordingly, the als-mutant strain shows a simultaneous inability to alkalinize internal and external media | Lactococcus lactis |
metabolism | strain IL1403 is able to cometabolize pyruvate and glucose at low pH, producing lactate, acetate as well as diacetyl/acetoin compounds. The enzyme is involved in the pyruvate metabolism in Lactococcus lactis, overview | Lactococcus lactis |
physiological function | the enzyme contributes to pH homeostasis in acid stress conditions | Lactococcus lactis |