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Literature summary for 2.2.1.6 extracted from
- Docking and 3D-QSAR studies of acetohydroxy acid synthase inhibitor sulfonylurea derivatives (2009), J. Mol. Model., 16, 951-964.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ethyl 2-([(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate | compound binds within a pocket of the enzyme formed by amino acid residues Met351, Asp375, Arg377, Gly509, Met570 and Val571 | Escherichia coli |  |
| ethyl 2-([(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl)benzoate | compound binds within a pocket of the enzyme formed by amino acid residues Met351, Asp375, Arg377, Gly509, Met570 and Val571 | Escherichia coli | |
| additional information | bulky substitutions in ortho-position of the sulfamoyl group in N-[(4-chloropyrimidin-2-yl)carbamoyl]benzenesulfonamide may enhance inhibitory activity. Negative charge distributed over a large surface area may enhance this activity. For better activity, the number of electronegative atoms present in the molecule should be high | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
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Release 2023.1 (January 2023)
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