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Literature summary for 2.2.1.6 extracted from
- Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach (2007), Bioorg. Med. Chem., 15, 374-380.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is an important target for design of environmental-benign herbicides | Brassica rapa subsp. oleifera |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate | inhibition profile and inhibition of root growth, overview | Brassica rapa subsp. oleifera |  |
| 3-(7H-cyclopenta[b]pyridin-5-yl)-N-[(2-nitrophenyl)sulfanyl]alanine | inhibition profile and inhibition of root growth, overview | Brassica rapa subsp. oleifera | |
| 6,6'-disulfanediyldipyridine-3-carboxylic acid | inhibition profile and inhibition of root growth, overview | Brassica rapa subsp. oleifera | |
| chlorimuron ethyl | a sulfonylurea herbicide | Brassica rapa subsp. oleifera | |
| imazapyr | an imidazolinone herbicide | Brassica rapa subsp. oleifera | |
| additional information | computational database screening for non-sulfonylurea inhibitors of AHAS, overview | Brassica rapa subsp. oleifera |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Brassica rapa subsp. oleifera | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | Brassica rapa subsp. oleifera | the enzyme catalyzes the first committed step in the biosynthesis of valine, leucine, and isoleucine | 2-acetolactate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brassica rapa subsp. oleifera | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| root | - |
Brassica rapa subsp. oleifera | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | - |
Brassica rapa subsp. oleifera | 2-acetolactate + CO2 | - |
? | |
| pyruvate | the enzyme catalyzes the first committed step in the biosynthesis of valine, leucine, and isoleucine | Brassica rapa subsp. oleifera | 2-acetolactate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetohydroxy acid synthase | - |
Brassica rapa subsp. oleifera |
| AHAS | - |
Brassica rapa subsp. oleifera |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Brassica rapa subsp. oleifera |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Brassica rapa subsp. oleifera |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Brassica rapa subsp. oleifera | |
| thiamine diphosphate | - |
Brassica rapa subsp. oleifera | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0152 | - |
6,6'-disulfanediyldipyridine-3-carboxylic acid | pH 7.0, 37°C | Brassica rapa subsp. oleifera | |
| 0.0421 | - |
(2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate | pH 7.0, 37°C | Brassica rapa subsp. oleifera | |
| 0.0907 | - |
3-(7H-cyclopenta[b]pyridin-5-yl)-N-[(2-nitrophenyl)sulfanyl]alanine | pH 7.0, 37°C | Brassica rapa subsp. oleifera | |
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