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Literature summary for 2.1.3.2 extracted from

  • Jacobson, G.R.; Stark, G.R.
    Aspartate transcarbamylase of Escherichia coli. Mechanisms of inhibition and activation by dicarboxylic acids and other anions (1975), J. Biol. Chem., 250, 6852-6860.
    View publication on PubMed
Search for more literature for 2.1.3.2

Activating Compound

Activating Compound Comment Organism Structure
L-malate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli
mesotartrate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli
succinate activation in presence of excess carbamoyl phosphate and limiting L-aspartate Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2,2-dimethylsuccinate
-
 Escherichia coli
acetate
-
 Escherichia coli
Cl-
-
 Escherichia coli
fumarate
-
 Escherichia coli
L-malate
-
 Escherichia coli
Maleate
-
 Escherichia coli
mesotartrate
-
 Escherichia coli
succinate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoylphosphate + L-aspartate Escherichia coli
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-aspartate
-
 Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
 ?
carbamoylphosphate + L-aspartate
-
 Escherichia coli phosphate + N-carbamoyl-L-aspartate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.17
-
 Maleate inhibition of catalytic subunits, C3 Escherichia coli
0.7
-
 mesotartrate inhibition of catalytic subunits, C3 Escherichia coli
1.1
-
 chloride inhibition of catalytic subunits, C3 Escherichia coli
2.2
-
 2,2-dimethylsuccinate inhibition of catalytic subunits, C3 Escherichia coli
3.5
-
 succinate inhibition of catalytic subunits, C3 Escherichia coli
5.3
-
 fumarate inhibition of catalytic subunits, C3 Escherichia coli