Literature summary for 2.1.3.2 extracted from

Laing, N.; Chan, W.W.C.; Hutchinson, D.W.; �berg, B.
Phosphorus-containing inhibitors of aspartate transcarbamoylase from Escherichia coli (1990), FEBS Lett., 260, 206-208.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Carbonyldiphosphonate	-	Escherichia coli
dichlormethylenediphosphonate	-	Escherichia coli
diphosphate	-	Escherichia coli
Diphosphate analogues	-	Escherichia coli
hypophosphate	-	Escherichia coli
imidodiphosphonate	-	Escherichia coli
Methylenediphosphonate	-	Escherichia coli
N-(Phosphonoacetyl)-L-aspartate	-	Escherichia coli
N-Diphosphoryl-L-aspartate	-	Escherichia coli
N-phosphoryl-L-aspartate	-	Escherichia coli
N-pyrophosphoryl-L-aspartate	-	Escherichia coli
O-phosphonoacetyl-oxosuccinate	-	Escherichia coli
Phosphonoacetate	-	Escherichia coli
Phosphonoformate	-	Escherichia coli
phosphonopropionate	-	Escherichia coli
S-diphosphoryl-mercaptosuccinate	-	Escherichia coli
S-phosphonoacetyl-mercaptosuccinate	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
carbamoylphosphate + L-aspartate	Escherichia coli	-	phosphate + N-carbamoyl-L-aspartate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate	reaction proceeds via a nucleophilic attack by the free amino group of L-aspartate on the carbon of carbamoylphosphate	Escherichia coli	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
carbamoyl phosphate + L-aspartate	-	Escherichia coli	phosphate + N-carbamoyl-L-aspartate	-	?
carbamoylphosphate + L-aspartate	-	Escherichia coli	phosphate + N-carbamoyl-L-aspartate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000027	-	N-(phosphonacetyl)-L-aspartate	-	Escherichia coli
0.00024	-	N-pyrophosphoryl-L-aspartate	-	Escherichia coli
0.002	-	O-phosphonoacetyl-oxosuccinate	-	Escherichia coli
0.0035	-	Carbonyldiphosphonate	-	Escherichia coli
0.0055	-	S-phosphonoacetyl-mercaptosuccinate	-	Escherichia coli
0.017	-	S-diphosphoryl-mercaptosuccinate	-	Escherichia coli
0.02	-	hypophosphate	-	Escherichia coli
0.022	-	Phosphonoformate	-	Escherichia coli
0.032	-	dichlormethylenediphosphonate	-	Escherichia coli
0.037	-	Methylenediphosphonate	-	Escherichia coli
0.05	-	N-phosphoryl-L-aspartate	-	Escherichia coli
0.051	-	diphosphate	-	Escherichia coli
0.071	-	imidodiphosphonate	-	Escherichia coli
0.15	-	Phosphonoacetate	-	Escherichia coli
0.175	-	peroxydiphosphonate	-	Escherichia coli
2	-	ethylamidocarbonylphosphonate	-	Escherichia coli
7.5	-	3-phosphonopropanoic acid	-	Escherichia coli

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Release 2023.1 (January 2023)