Cloned (Comment) | Organism |
---|---|
possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively, and both gene products are predicted to carry a bipartite targeting signal | Toxoplasma gondii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apicoplast | both the methionyl-tRNA formyltransferase and peptide deformylase are localized to the apicoplast only | Toxoplasma gondii | 20011 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + L-methionyl-tRNAfMet | Toxoplasma gondii | - |
tetrahydrofolate + N-formylmethionyl-tRNAfMet | - |
? | |
10-formyltetrahydrofolate + L-methionyl-tRNAfMet | Toxoplasma gondii RH | - |
tetrahydrofolate + N-formylmethionyl-tRNAfMet | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Toxoplasma gondii | - |
possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively | - |
Toxoplasma gondii RH | - |
possesses a single gene coding for each FMT and peptide deformylase, PDF, respectively | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
tachyzoite | - |
Toxoplasma gondii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + L-methionyl-tRNAfMet | - |
Toxoplasma gondii | tetrahydrofolate + N-formylmethionyl-tRNAfMet | - |
? | |
10-formyltetrahydrofolate + L-methionyl-tRNAfMet | - |
Toxoplasma gondii RH | tetrahydrofolate + N-formylmethionyl-tRNAfMet | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMT | - |
Toxoplasma gondii |
methionyl-tRNA formyltransferase | - |
Toxoplasma gondii |
General Information | Comment | Organism |
---|---|---|
metabolism | formylmethionine-independent initiation of translation in apicomplexans, the requirement for an initiation by a specialized tRNA charged with formylmethionine is bypassed in the mitochondrion of these parasites, the formylated methionine used during initiation is deformylated on the nascent peptide by a peptide deformylase | Toxoplasma gondii |
additional information | in Toxoplasma gondii the absence of mitochondrial tRNA genes is compensated for by the import of cytosolic eukaryotic tRNAs. Although all compartments require a complete set of charged tRNAs, the apicomplexan nuclear genomes do not hold sufficient aminoacyl-tRNA synthetase genes to be targeted individually to each compartment. The absence of tRNAMet formyltransferase and peptide deformylase implies that the requirement for a specialized formylmethionyl-tRNAMet for translation initiation is bypassed in the mitochondrion | Toxoplasma gondii |