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Literature summary for 2.1.2.3 extracted from

  • Ha, T.; Morgan, S.L.; Vaughn, W.H; Eto, I.; Baggott, J.E.
    Detection of inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase by thioinosinic acid and azathioprine by a new colorimetric assay (1990), Biochem. J., 272, 339-342.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine
-
Homo sapiens
medicine
-
Gallus sp.
medicine animal model of systemic autoimmune disease Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-acetamidophenol
-
Gallus sp.
Azathioprine competitive inhibitor Gallus sp.
Azathioprine
-
Mus musculus
Ibuprofen anti-inflammatory drug Gallus sp.
Ibuprofen anti-inflammatory drug Mus musculus
naproxen anti-inflammatory drug Gallus sp.
naproxen anti-inflammatory drug Mus musculus
paracetamol
-
Gallus sp.
sulphalazine
-
Homo sapiens
thioinosinic acid competitive inhibitor Gallus sp.
thioinosinic acid
-
Mus musculus
tylenol
-
Gallus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Mus musculus
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp.
-
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r

Organism

Organism UniProt Comment Textmining
Gallus sp.
-
chicken
-
Homo sapiens
-
human
-
Mus musculus
-
mouse, strain MRL/lpr
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Gallus sp.
-
lymphocyte
-
Homo sapiens
-
peripheral blood mononuclear cell
-
Mus musculus
-
peripheral blood mononuclear cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Mus musculus tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
r
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Mus musculus ?
-
?
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
?
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
?
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Mus musculus tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.039
-
thioinosinic acid
-
Gallus sp.
0.09
-
Azathioprine
-
Mus musculus
0.11
-
thioinosinic acid
-
Mus musculus
0.12
-
Azathioprine
-
Gallus sp.