Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | - |
Gallus sp. |
medicine | animal model of systemic autoimmune disease | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-acetamidophenol | - |
Gallus sp. | |
Azathioprine | competitive inhibitor | Gallus sp. | |
Azathioprine | - |
Mus musculus | |
Ibuprofen | anti-inflammatory drug | Gallus sp. | |
Ibuprofen | anti-inflammatory drug | Mus musculus | |
naproxen | anti-inflammatory drug | Gallus sp. | |
naproxen | anti-inflammatory drug | Mus musculus | |
paracetamol | - |
Gallus sp. | |
sulphalazine | - |
Homo sapiens | |
thioinosinic acid | competitive inhibitor | Gallus sp. | |
thioinosinic acid | - |
Mus musculus | |
tylenol | - |
Gallus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Mus musculus | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus sp. | - |
chicken | - |
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse, strain MRL/lpr | - |
Purification (Comment) | Organism |
---|---|
- |
Gallus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Gallus sp. | - |
lymphocyte | - |
Homo sapiens | - |
peripheral blood mononuclear cell | - |
Mus musculus | - |
peripheral blood mononuclear cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Mus musculus | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Mus musculus | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Mus musculus | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
thioinosinic acid | - |
Gallus sp. | |
0.09 | - |
Azathioprine | - |
Mus musculus | |
0.11 | - |
thioinosinic acid | - |
Mus musculus | |
0.12 | - |
Azathioprine | - |
Gallus sp. |