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Literature summary for 2.1.2.3 extracted from

  • Smith, G.K.; Mueller, T.; Benkovic, P.A.; Benkovic, S.J.
    On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver (1981), Biochemistry, 20, 1241-1245.
    View publication on PubMed
Search for more literature for 2.1.2.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0679
-
 10-formyltetrahydrofolate
-
 Gallus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. reduced folate cofactor requiring step of de novo purine biosynthesis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

Organism UniProt Comment Textmining
Gallus sp.
-
 chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyl-8-deazafolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide
-
 Gallus sp. 8-deazafolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 ?
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide reduced folate cofactor requiring step of de novo purine biosynthesis Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r