Application | Comment | Organism |
---|---|---|
medicine | - |
Gallus sp. |
medicine | target for development of inhibitors with potential use as chemotherapeutic agents | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloned and expressed | Salmonella enterica subsp. enterica serovar Typhimurium |
cloned and expressed | Bacillus subtilis |
cloned and expressed | Escherichia coli |
purH gene cloning and sequencing of cDNA | Gallus sp. |
purH gene, cloning and sequencing of cDNA, expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Gallus sp. | |
4-amino-10-methylpteroylglutamic acid | methotrexate, non-competitive inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0168 | - |
5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens | |
0.0602 | - |
(6R,6S)-10-formyltetrahydrofolic acid | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64425 | - |
1 * 64425, calculated from amino acid sequence | Homo sapiens |
64430 | - |
cDNA sequencing | Homo sapiens |
64450 | - |
electrospray mass spectroscopy | Homo sapiens |
65630 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Bacillus subtilis | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Escherichia coli | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Escherichia coli | - |
- |
- |
Gallus sp. | - |
avian | - |
Homo sapiens | P31939 | human | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | leukemia cell, T lymphoblastoid cell line | Homo sapiens | - |
MCF-7 cell | breast cancer cell | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.19 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6R,6S)-10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Bacillus subtilis | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Escherichia coli | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Bacillus subtilis | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Escherichia coli | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Bacillus subtilis | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Escherichia coli | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 64425, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase | bifunctional enzyme | Homo sapiens |
AICARFT | - |
Homo sapiens |
AICARFT/IMPCHase | - |
Homo sapiens |