Application | Comment | Organism |
---|---|---|
diagnostics | increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
enzyme expression analysis in hepatocellular carcinoma cell lines, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockdown by siRNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22102 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BEL-7404 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | enzyme expression and functional significance in hepatocellular carcinoma cells from several patients, overview | Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
MHCC97H cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GART | - |
Homo sapiens |
glycinamide ribonucleotide transformylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of the enzyme by small interfering RNA inhibits cell proliferation and blocks S-phase and mitotic entry in cultured Hep-G2 and BEL-7404 cells. Enzyme depletion decreases the proliferating cell nuclear antigen concentration | Homo sapiens |
metabolism | glycinamide ribonucleotide transformylase is a folate-dependent enzyme in the de novo purine pathway | Homo sapiens |
physiological function | increased expression of glycinamide ribonucleotide transformylase promotes liver cancer cell proliferation, enzyme expression and functional significance in hepatocellular carcinoma cells from several patients, overview | Homo sapiens |