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Literature summary for 2.1.2.2 extracted from

  • Antle, V.D.; Liu, D.; McKellar, B.R.; Caperelli, C.A.; Hua, M.; Vince, R.
    Substrate specificity of glycinamide ribonucleotide transformylase from chicken liver (1996), J. Biol. Chem., 271, 6045-6049.
    View publication on PubMed

Application

Application Comment Organism
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0101
-
beta-glycinamide ribonucleotide
-
Gallus gallus
0.0369
-
carbocyclic beta-glycinamide ribonucleotide
-
Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Gallus gallus
-
chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + (alpha,beta)-glycinamide ribonucleotide
-
Gallus gallus tetrahydrofolate + formylglycinamide ribonucleotide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
?
10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
Gallus gallus tetrahydrofolate + formyl glycinamide ribonucleotide
-
?
additional information
-
Escherichia coli ?
-
?
additional information glycinamide ribonucleotide nucleoside is no substrate Gallus gallus ?
-
?