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Literature summary for 2.1.2.2 extracted from

  • Antle, V.D.; Donat, N.; Hua, M.; Liao, P.L.; Vince, R.; Caperelli, C.A.
    Substrate specificity of human glycinamide ribonucleotide transformylase (1999), Arch. Biochem. Biophys., 370, 231-235.
    View publication on PubMed
Search for more literature for 2.1.2.2

Application

Application Comment Organism
medicine
-
 Escherichia coli
medicine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloned and expressed in Escherichia coli HMS174(DE3)/pCC12 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxy-2',3'-didehydro-carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
2',3'-dideoxy-carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
5'-phosphonate carbocyclic glycinamide ribonucleotide
-
 Homo sapiens
5,10-dideazatetrahydrofolate
-
 Escherichia coli
5,10-dideazatetrahydrofolate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0011
-
 beta-glycinamide ribonucleotide
-
 Homo sapiens
0.0036
-
 carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens
0.0101
-
 beta-glycinamide ribonucleotide
-
 Gallus gallus
0.0369
-
 carbocyclic beta-glycinamide ribonucleotide
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Gallus gallus
-
 chicken
-
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, expressed in E. coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide
-
 Escherichia coli 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide
-
 ?
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Gallus gallus tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + formyl glycinamide ribonucleotide
-
 ?
10-formyltetrahydrofolate + O-phosphonate carbocyclic glycinamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + O-phosphonate-ribosyl-N-formylglycinamide
-
 ?
additional information
-
 Gallus gallus ?
-
 ?
additional information
-
 Escherichia coli ?
-
 ?
additional information alpha-glycinamide ribonucleotide and glycinamide ribonucleotide nucleoside are neither substrates for no inhibitors Homo sapiens ?
-
 ?