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Literature summary for 2.1.2.2 extracted from

  • Almassy, R.J.; Janson, C.A.; Kann, C.C.; Hostomska, Z.
    Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase (1992), Proc. Natl. Acad. Sci. USA, 89, 6114-6118.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.2.2

Application

Application Comment Organism
medicine target for structure-based drug design Escherichia coli
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Mus musculus
medicine pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
coding region of Escherichia coli GART amplified from chromosomal DNA with PCR method Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals grown at 20°C by hanging-drop vapor diffusion, space group C222, a = 140.9 A, b = 97.6 A, c = 102.4 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5,10-dideaza-5,6,7,8-tetrahydrofolate
-
 Escherichia coli
5,10-dideazatetrahydrofolate
-
 Escherichia coli
5,10-dideazatetrahydrofolate
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23240
-
 amino acid sequence, deduced from nucleotide sequence Escherichia coli
100000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
additional information
-
 Escherichia coli ?
-
 ?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
GART
-
 Escherichia coli