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Literature summary for 2.1.2.2 extracted from

  • Caperelli, C.A.; Chettur, G.; Lin, L.Y.; Benkovic, S.J.
    Purification of glycineamide ribonucleotide transformylase (1978), Biochem. Biophys. Res. Commun., 82, 403-410.
    View publication on PubMed
Search for more literature for 2.1.2.2

Activating Compound

Activating Compound Comment Organism Structure
NH4+ activity enhanced by Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activity enhanced by Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 2 * 63000, transformylase, homodimer, SDS-PAGE Gallus gallus
83000
-
 2 * 83000, trifunctional protein, SDS-PAGE Gallus gallus
100000
-
 protein possessing transformylase activity, sucrose density gradient ultracentrifugation Gallus gallus
150000
-
 gel filtration Saccharomyces cerevisiae
160000
-
 trifunctional protein, sucrose density gradient ultracentrifugation Gallus gallus
201000
-
 gel filtration Ovis aries
218000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Gallus gallus
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Sus scrofa
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Saccharomyces cerevisiae
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Ovis aries
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
 chicken
-
Ovis aries
-
 sheep
-
Saccharomyces cerevisiae
-
 yeast
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
purified in combination with formyl-methenyl-methylenetetrahydrofolate synthetase Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Sus scrofa
-
liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.294
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Gallus gallus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Sus scrofa tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Saccharomyces cerevisiae tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Ovis aries tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Gallus gallus ?
-
 ?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Sus scrofa ?
-
 ?
additional information 3 activities in a multifunctional protein, posessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotidetransformylase and aminoimidazole ribonucleotide synthetase Ovis aries ?
-
 ?

Subunits

Subunits Comment Organism
dimer homodimer Gallus gallus
dimer homodimer Saccharomyces cerevisiae
dimer homodimer Ovis aries
dimer 2 * 63000, transformylase, homodimer, SDS-PAGE Gallus gallus
dimer 2 * 83000, trifunctional protein, SDS-PAGE Gallus gallus
monomer
-
 Gallus gallus
monomer
-
 Sus scrofa
monomer
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
L-(+-)-5,10-methenyltetrahydrofolate
-
 Gallus gallus