Inhibitors | Comment | Organism | Structure |
---|---|---|---|
formaldehyde | inactivation | Escherichia coli | |
formaldehyde | inactivation | Psychromonas ingrahamii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | steady-state kinetics | Escherichia coli | |
additional information | - |
additional information | steady-state kinetics | Psychromonas ingrahamii | |
0.3 | - |
L-serine | pH 7.2, 20°C | Escherichia coli | |
0.4 | - |
L-serine | pH 7.2, 20°C | Psychromonas ingrahamii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | Escherichia coli | - |
tetrahydrofolate + L-serine | - |
r | |
5,10-methylenetetrahydrofolate + glycine + H2O | Psychromonas ingrahamii | - |
tetrahydrofolate + L-serine | - |
r | |
5,10-methylenetetrahydrofolate + glycine + H2O | Psychromonas ingrahamii 37 | - |
tetrahydrofolate + L-serine | - |
r | |
additional information | Psychromonas ingrahamii | SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity | ? | - |
? | |
additional information | Psychromonas ingrahamii 37 | SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity | ? | - |
? | |
tetrahydrofolate + L-serine | Escherichia coli | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
tetrahydrofolate + L-serine | Psychromonas ingrahamii | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
tetrahydrofolate + L-serine | Psychromonas ingrahamii 37 | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A825 | gene glyA | - |
Psychromonas ingrahamii | A1SUU0 | gene glyA | - |
Psychromonas ingrahamii 37 | A1SUU0 | gene glyA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | - |
Escherichia coli | tetrahydrofolate + L-serine | - |
r | |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
Psychromonas ingrahamii | tetrahydrofolate + L-serine | - |
r | |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
Psychromonas ingrahamii 37 | tetrahydrofolate + L-serine | - |
r | |
additional information | SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity | Psychromonas ingrahamii | ? | - |
? | |
additional information | SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity | Psychromonas ingrahamii 37 | ? | - |
? | |
tetrahydrofolate + L-serine | - |
Escherichia coli | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
tetrahydrofolate + L-serine | - |
Psychromonas ingrahamii | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r | |
tetrahydrofolate + L-serine | - |
Psychromonas ingrahamii 37 | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
serine hydroxymethyltransferase | - |
Escherichia coli |
serine hydroxymethyltransferase | - |
Psychromonas ingrahamii |
SHMT | - |
Escherichia coli |
SHMT | - |
Psychromonas ingrahamii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Escherichia coli |
20 | - |
assay at | Psychromonas ingrahamii |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
9.25 | - |
L-serine | pH 7.2, 20°C | Psychromonas ingrahamii | |
13.17 | - |
L-serine | pH 7.2, 20°C | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Escherichia coli |
7.2 | - |
assay at | Psychromonas ingrahamii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,10-methylenetetrahydrofolate | - |
Escherichia coli | |
5,10-methylenetetrahydrofolate | - |
Psychromonas ingrahamii | |
pyridoxal 5'-phosphate | dependent on | Escherichia coli | |
pyridoxal 5'-phosphate | dependent on | Psychromonas ingrahamii | |
tetrahydrofolate | - |
Escherichia coli | |
tetrahydrofolate | - |
Psychromonas ingrahamii |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
23.13 | - |
L-serine | pH 7.2, 20°C | Psychromonas ingrahamii | |
43.88 | - |
L-serine | pH 7.2, 20°C | Escherichia coli |