Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corynebacterium glutamicum | - |
strain ATCC13032 | - |
Corynebacterium glutamicum ATCC 13032 | - |
strain ATCC13032 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0385 | - |
in the presence of glycine, in 200 mM HEPES buffer, pH 7.0 | Corynebacterium glutamicum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + tetrahydrofolate | - |
Corynebacterium glutamicum | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Corynebacterium glutamicum ATCC 13032 | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine hydroxymethyltransferase | - |
Corynebacterium glutamicum |
SHMT | - |
Corynebacterium glutamicum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Corynebacterium glutamicum |
Organism | Comment | Expression |
---|---|---|
Corynebacterium glutamicum | about 3fold increase of SHMT activity during exponential growth with a further increase at the onset of the stationary phase, the essential SHMT has highest activity in the stationary phase and the regulator GlyR acts as an activator of transcription in this growth phase. Addition of glycine results in a slight but significant increase of SHMTactivity by 75% | up |