Literature summary for 2.1.1.8 extracted from

Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria (2009), Allergy, 64, 213-221.

Search for more literature for 2.1.1.8

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HMC-1 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the A939G polymorphism is significantly associated with the aspirin intolerant chronic urticaria phenotype, while no association is found with the C314T polymorphism, the 939A allele gives lower levels of HNMT mRNA stability, HNMT protein expression, and HNMT enzymatic activity and higher histamine release than the 939G allele, patients with the 939A allele have lower HNMT activity in red blood cell lysates and higher histamine release from their basophils	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histamine	-	Homo sapiens	S-adenosyl-L-homocysteine + Ntau-methylhistamine	-	?

Synonyms

Synonyms	Comment	Organism
HNMT	-	Homo sapiens

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Release 2023.1 (January 2023)