Cloned (Comment) | Organism |
---|---|
expressed in HMC-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the A939G polymorphism is significantly associated with the aspirin intolerant chronic urticaria phenotype, while no association is found with the C314T polymorphism, the 939A allele gives lower levels of HNMT mRNA stability, HNMT protein expression, and HNMT enzymatic activity and higher histamine release than the 939G allele, patients with the 939A allele have lower HNMT activity in red blood cell lysates and higher histamine release from their basophils | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + histamine | - |
Homo sapiens | S-adenosyl-L-homocysteine + Ntau-methylhistamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HNMT | - |
Homo sapiens |