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Literature summary for 2.1.1.8 extracted from
- S-adenosylmethionine dependent transmethylation of histamine: Purification and partial characterization of guinea pig brain and rat kidney histamine N-methyltransferase (1985), Adv. Biosci., 51, 163-172.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosylhomocysteine | - |
Cavia porcellus |  |
| S-adenosylhomocysteine | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, 3 months | Cavia porcellus |
| -80°C, 3 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histamine | - |
Cavia porcellus | S-adenosyl-L-homocysteine + Ntau-methylhistamine | - |
? | |
| S-adenosyl-L-methionine + histamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + Ntau-methylhistamine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
2 optima at pH 7.5 and pH 9.0, brain enzyme | Cavia porcellus |
| 8.5 | 9 | kidney enzyme | Rattus norvegicus |
| 9 | - |
- |
Cavia porcellus |
| 9 | - |
kidney | Rattus norvegicus |
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