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Literature summary for 2.1.1.79 extracted from
- Cyclopropane fatty acid synthase of Escherichia coli. Stabilization, purification, and interaction with phospholipid vesicles (1979), Biochemistry, 18, 3292-3300.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) | reversed by addition of dithiothreitol | Escherichia coli |  |
| NEM | - |
Escherichia coli | |
| p-hydroxymercuribenzoate | - |
Escherichia coli | |
| S-adenosylhomocysteine | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.09 | - |
S-adenosyl-L-methionine | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | loosely associated with the inner membrane | Escherichia coli | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
equilibrium sedimentation, gel filtration | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + phospholipid olefinic fatty acid | Escherichia coli | methylation of unsaturated fatty acid moieties of phospholipids in the phospholipid bilayer | S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Escherichia coli |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000113 | - |
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + cardiolipin | - |
Escherichia coli | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + phosphatidylethanolamine | - |
Escherichia coli | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + phosphatidylglycerol | - |
Escherichia coli | S-adenosyl-L-homocysteine + ? | - |
? | |
| S-adenosyl-L-methionine + phospholipid olefinic fatty acid | reaction is not affected by the order-disorder state of the lipid substrate | Escherichia coli | S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid | - |
? | |
| S-adenosyl-L-methionine + phospholipid olefinic fatty acid | methylation of unsaturated fatty acid moieties of phospholipids in the phospholipid bilayer | Escherichia coli | S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 90000, SDS-PAGE | Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.22 | - |
S-adenosylhomocysteine | - |
Escherichia coli | |
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