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Literature summary for 2.1.1.77 extracted from

  • Cournoyer, P.; Desrosiers, R.R.
    Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway (2009), Neuropharmacology, 56, 839-848.
    View publication on PubMed
Search for more literature for 2.1.1.77

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
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 Homo sapiens
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U-87MG cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + delta-sleep-inducing peptide L-isoaspartate
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 Homo sapiens S-adenosyl-L-homocysteine + delta-sleep-inducing peptide L-aspartate alpha-methyl ester
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 ?

Synonyms

Synonyms Comment Organism
PIMT
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 Homo sapiens
protein L-isoaspartyl methyltransferase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 5 mM valproic acid enhances protein L-isoaspartyl methyltransferase expression about 2fold through glycogen synthase kinase-3/beta-catenin requires 90 kDa ribosomal S6 kinase. Src, c-Raf, MEK1/2 and extracellular-regulated kinase 1/2 abolish the extracellular-regulated kinase 1/2 phosphorylation stimulated by valproic acid, thus preventing PIMT induction by valproic acid up