Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | repair enzyme that acts upon damaged proteins bearing abnormal aspartyl residues | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anaplastic astrocytoma cell | 69% reduced PIMT expression as compared to normal brains | Homo sapiens | - |
astrocytoma cell | enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III), 80% reduced PIMT expression in glioblastomas (grade IV) as compared to normal brains | Homo sapiens | - |
astrocytoma cell | enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III) | Homo sapiens | - |
brain | - |
Homo sapiens | - |
glioblastoma cell | 80% reduced PIMT expression as compared to normal brains | Homo sapiens | - |
pilocytic astrocytoma cell | 76% reduced PIMT expression as compared to normal brain | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein L-isoaspartate | repair enzyme that acts upon damaged proteins bearing abnormal aspartyl residues | Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-isoaspartyl methyltransferase | - |
Homo sapiens |
PIMT | - |
Homo sapiens |