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Literature summary for 2.1.1.77 extracted from

  • Lapointe, M.; Lanthier, J.; Moumdjian, R.; Regina, A.; Desrosiers, R.R.
    Expression and activity of L-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors (2005), Mol. Brain Res., 135, 93-103.
    View publication on PubMed
Search for more literature for 2.1.1.77

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens repair enzyme that acts upon damaged proteins bearing abnormal aspartyl residues S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
anaplastic astrocytoma cell 69% reduced PIMT expression as compared to normal brains Homo sapiens
-
astrocytoma cell enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III), 80% reduced PIMT expression in glioblastomas (grade IV) as compared to normal brains Homo sapiens
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astrocytoma cell enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III) Homo sapiens
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brain
-
 Homo sapiens
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glioblastoma cell 80% reduced PIMT expression as compared to normal brains Homo sapiens
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pilocytic astrocytoma cell 76% reduced PIMT expression as compared to normal brain Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate repair enzyme that acts upon damaged proteins bearing abnormal aspartyl residues Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
L-isoaspartyl methyltransferase
-
 Homo sapiens
PIMT
-
 Homo sapiens