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Literature summary for 2.1.1.77 extracted from

  • Lanthier, J.; Desrosiers, R.R.
    Protein L-isoaspartyl methyltransferase repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration (2004), Exp. Cell Res., 293, 96-105.
    View publication on PubMed

Application

Application Comment Organism
medicine L-isoaspartyl residue formation in extracellular matrix proteins such as type -I collagen could play an important role in reducing cell migration. PIMT could be a therapeutic tool to restore normal cell migration in pathological conditions where cell motility is crucial Drosophila sp. (in: flies)

Organism

Organism UniProt Comment Textmining
Drosophila sp. (in: flies)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein L-isoaspartate repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration Drosophila sp. (in: flies) S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
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Synonyms

Synonyms Comment Organism
L-isoaspartyl methyltransferase
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Drosophila sp. (in: flies)