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Literature summary for 2.1.1.72 extracted from

  • Hernday, A.D.; Braaten, B.A.; Low, D.A.
    The mechanism by which DNA adenine methylase and PapI activate the pap epigenetic switch (2003), Mol. Cell, 12, 947-957.
    View publication on PubMed
Search for more literature for 2.1.1.72

Protein Variants

Protein Variants Comment Organism
additional information no methylation of the TGATCprox site after mutation of the site, and subsequently no PapI-dependent binding of Lrp to binding sites 1-3 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine Escherichia coli methylation of the site GATCprox proximal to the promotor is required for transition to the phase On state by specifically blocking PapI-dependent binding of Lrp to promotor proximal sites 4-6, expression of pyelonephritis-associated pili, i.e. Pap, in uropathogenic Escherichia coli is epigenetically controlled by a reversible OFF to ON switch, overview S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + DNA adenine methylation of the site GATCprox proximal to the promotor is required for transition to the phase On state by specifically blocking PapI-dependent binding of Lrp to promotor proximal sites 4-6, expression of pyelonephritis-associated pili, i.e. Pap, in uropathogenic Escherichia coli is epigenetically controlled by a reversible OFF to ON switch, overview Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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 ?
S-adenosyl-L-methionine + DNA adenine methylation of target sequence GATC Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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 ?

Synonyms

Synonyms Comment Organism
Dam
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 Escherichia coli
DNA adenine methylase
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 Escherichia coli