Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.71 extracted from

  • Schneider, W.J.; Vance, D.E.
    Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities (1979), J. Biol. Chem., 254, 3886-3891.
    View publication on PubMed
Search for more literature for 2.1.1.71

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylcholine inhibits the incorporation of [3H]-methyl groups from S-adenosyl-L-methionine into phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
S-adenosyl-L-homocysteine competitive inhibition Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 S-adenosyl-L-methionine substrate phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
0.022
-
 S-adenosyl-L-methionine
-
 Rattus norvegicus
0.08
-
 phosphatidyl-N-monomethylethanolamine
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus
-
 rat
-
Rattus norvegicus Wistar
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.79
-
-
 Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, not stable to freezing Rattus norvegicus
2°C, loses 30% of its activity within 12 h Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2 S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine
-
 Rattus norvegicus Wistar S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
-
 Rattus norvegicus Wistar S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine
-
 ?
S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine
-
 Rattus norvegicus Wistar S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine
-
 ?
S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-monomethylethanolamine
-
 ?
S-adenosyl-L-methionine + phosphatidylethanolamine
-
 Rattus norvegicus Wistar S-adenosyl-L-homocysteine + phosphatidyl-N-monomethylethanolamine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.5 9.5
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0049
-
 S-adenosyl-L-homocysteine
-
 Rattus norvegicus
0.0067
-
 S-adenosyl-L-homocysteine inhibition of the last step in the synthesis of phosphatidylcholine Rattus norvegicus