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Literature summary for 2.1.1.64 extracted from

  • Hsu, A.Y.; Poon, W.W.; Shepherd, J.A.; Myles, D.C.; Clarke, C.F.
    Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis (1996), Biochemistry, 35, 9797-9806.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 3-demethylubiquinol-8 Escherichia coli the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8 S-adenosyl-L-homocysteine + ubiquinol-8
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3-demethylubiquinol-3 i.e. 5-((2E,6E)-farnesyl)-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone Escherichia coli S-adenosyl-L-homocysteine + ubiquinol-3
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 ?
S-adenosyl-L-methionine + 3-demethylubiquinol-8 the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8 Escherichia coli S-adenosyl-L-homocysteine + ubiquinol-8
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 ?

Synonyms

Synonyms Comment Organism
UbiG
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 Escherichia coli
UbiG methyltransferase
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 Escherichia coli