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Literature summary for 2.1.1.63 extracted from

  • Li, X.; Qian, S.; Zheng, L.; Yang, B.; He, Q.; Hu, Y.
    A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells (2012), Org. Biomol. Chem., 10, 3189-3191.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa S3 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-benzylguanine) + protein L-cysteine
-
Homo sapiens DNA (without 6-O-benzylguanine) + protein S-benzyl-L-cysteine
-
?
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?
[N-[2-(2-[2-[(3-[[(2-amino-9H-purin-6-yl)oxy]methyl]phenyl)methoxy]ethoxy]ethoxy)ethyl]-5-(3,5-dimethyl-1H-pyrrol-2-yl-kappaN)-5-(3,5-dimethyl-2H-pyrrol-2-ylidene-kappaN)pentanamidato](difluoro)boron + [protein]-L-cysteine
-
Homo sapiens [protein]-S-methyl-L-cysteine + ?
-
?

Synonyms

Synonyms Comment Organism
MGMT
-
Homo sapiens
O6-methylguanine-DNA methyltransferase
-
Homo sapiens