Literature summary for 2.1.1.63 extracted from

Wirtz, S.; Nagel, G.; Eshkind, L.; Neurath, M.F.; Samson, L.D.; Kaina, B.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis (2010), Carcinogenesis, 31, 2111-2117.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Mus musculus	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Mus musculus
O6-methylguanine-DNA methyltransferase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	O6-methylguanine-DNA methyltransferase-deficient mice show a higher colon cancer frequency than the wild type	Mus musculus
physiological function	O6-methylguanine reversal by the enzyme is required for protection against alkylation-induced colon carcinogenesis	Mus musculus

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Release 2023.1 (January 2023)