Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N,N'-bis(2-chloroethyl)-N-nitrosourea | BCNU | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | the results suggest that expression of MGMT could enhance the capacity of bone marrow-derived cells to repopulate lung epithelium, and when used in combination with a gene of interest, MGMT could have therapeutic applications | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
P140K | mutant confers resistance to N,N'-bis(2-chloroethyl)-N-nitrosourea and O(6)-benzylguanine | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
O(6)-benzylguanine | BG | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine | Mus musculus | - |
DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
lung epithelium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA (containing 6-O-methylguanine) + [protein]-L-cysteine | - |
Mus musculus | DNA (without 6-O-methylguanine) + [protein]-S-methyl-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGT | - |
Mus musculus |
methylguanine DNA methyltransferase | - |
Mus musculus |
MGMT | - |
Mus musculus |
O6-alkylguanine-DNA alkyltransferase | - |
Mus musculus |