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Literature summary for 2.1.1.63 extracted from

  • Hansen, R.J.; Nagasubramanian, R.; Delaney, S.M.; Samson, L.D.; Dolan, M.E.
    Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice (2007), Carcinogenesis, 28, 1111-1116.
    View publication on PubMed

Application

Application Comment Organism
medicine MGMT significantly protects against in vivo temozolomide-induced mutations Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information MGMT deficiency does not result in greater mutation frequency following cyclophosphamide or 1,3-bis (2-chloroethyl)-1-nitrosourea compared with wild-type mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
O6-benzylguanine pretreatment of Mgmt+/+ mice prior to 1,3-bis (2-chloroethyl)-1-nitrosourea does not result in significantly more mutations than mice treated with 1,3-bis (2-chloroethyl)-1-nitrosourea alone Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57BL/6 and F1 (C57BL/6 x 129/Sv) wild-type mice
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Mus musculus
-
T-lymphocyte
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
MGMT
-
Mus musculus
O6-methylguanine-DNA methyltransferase
-
Mus musculus