Literature summary for 2.1.1.63 extracted from

Rasimas, J.J.; Pegg, A.E.; Fried, M.G.
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase (2003), J. Biol. Chem., 278, 7973-7980.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	Homo sapiens	the protein protects the integrity of the genome, and it also contributes to the resistance of tumors to DNA-alkylating chemotherapeutic agents	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	the protein protects the integrity of the genome, and it also contributes to the resistance of tumors to DNA-alkylating chemotherapeutic agents	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?
DNA containing 6-O-methylguanine + [protein]-L-cysteine	DNA-binding mechanism	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
AGT	-	Homo sapiens
O6-alkylguanine-DNA alkyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)