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Literature summary for 2.1.1.63 extracted from

  • Baumann, R.P.; Shyam, K.; Penketh, P.G.; Remack, J.S.; Brent, T.P.; Sartorelli, A.C.
    1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity (2004), Cancer Chemother. Pharmacol., 53, 288-295.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methyl isocyanate methyl isocyanate resulting from base-catalyzed activation of VNP40101M inhibits the enzyme, thereby enhancing the yield of the DNA G-C interstrand crosslink responsible for the antitumor activity of this agent Homo sapiens
VNP40101M methyl isocyanate resulting from base-catalyzed activation of VNP40101M inhibits the enzyme, thereby enhancing the yield of the DNA G-C interstrand crosslink responsible for the antitumor activity of this agent Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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